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Breast Cancer

Based on current drug pricing strategies in the United States, ribociclib combination therapy is unlikely to be cost-effective for treating postmenopausal patients with HR-positive HER2-negative advanced breast cancer.
For patients with recurrent metastatic HER2-positive breast cancer, new therapies such as margetuximab will expand treatment options.
To help inform treatment decision-making, guidelines have been developed on surveillance mammography for early breast cancer survivors who are ≥75 years of age.
Patients reported satisfaction with nurse-led telephone end-of-treatment follow-up experiences; therefore, permanent modifications may be warranted.
Breast cancer survival disparities persist even after adjusting for sociodemographic factors, tumor characteristics, and NCCN guideline–appropriate treatment, suggesting that social and environmental factors can impact survival.
Interfacility variation in efforts to eliminate the use of unnecessary breast cancer procedures highlights the need for more formalized deimplementation plans.
A diagnosis of breast cancer can cause stress and depression, especially in younger women. According to findings from a recent clinical trial, behavioral interventions may help decrease symptoms of depression and reduce anxiety, fatigue, and sleep disturbances in younger breast cancer survivors.
Physicians often fail to perceive radiation-associated symptoms and the severity of those symptoms, according to the results of a large observational study that compared the reports of patients with breast cancer with physicians’ assessments of 4 common radiation-associated symptoms.
Results of the SWOG S1007 RxPONDER clinical trial suggest that many postmenopausal women with early-stage hormone receptor (HR)-positive, human epidermal growth receptor 2 (HER2)-negative breast cancer, and 1 to 3 positive axillary lymph nodes may be able to avoid adjuvant chemotherapy.
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