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Fostamatinib-Treated Patients with Persistent/Chronic ITP Maintained Long-Term Responses
ASH
Conference Correspondent
These study results showed that heavily pretreated patients with persistent/chronic immune thrombocytopenia (ITP) who achieved a stable response with fostamatinib therapy maintained their responses for ≥12 months.
Read More ›
Avatrombopag Superior to Placebo for the Treatment of Chronic ITP
ASH
Conference Correspondent
Results of this randomized, placebo-controlled phase 3 trial showed that avatrombopag was superior to placebo in terms of the cumulative number of weeks with a platelet response, platelet response at day 8, and durability of platelet response in patients with refractory chronic immune thrombocytopenia (ITP).
Read More ›
Subcutaneous Romiplostim Increased Platelet Response in Children with ITP
ASH
Conference Correspondent
This open-label study reported that the majority of children with immune thrombocytopenia (ITP) who received open-label romiplostim for ≥6 months achieved a platelet response, with median platelet counts >50 × 10
9
/L from week 12 onward and no new safety signals observed during the study period.
Read More ›
Questions About Treating Patients Using a CDK4/6 Inhibitor
By
Matthew P. Goetz, MD
Breast Cancer
,
Video
,
SABCS
Conference Correspondent
Dr Matthew Goetz addresses common questions that arise when patients with HER+ metastatic breast cancer have progressed on a CDK4/6 inhibitor plus an aromatase inhibitor.
Read More ›
The Use of Chemotherapy in the Metastatic Setting
By
Matthew P. Goetz, MD
Breast Cancer
,
Video
,
SABCS
Conference Correspondent
Dr Matthew Goetz believes that, as more mature data come into existence, the demonstration of a survival advantage will guide more patients with metastatic breast cancer to try CDK4/6 inhibitors plus aromatase inhibitors instead of chemotherapy.
Read More ›
The Mechanism of Action of CDK4/6 Inhibitors
By
Matthew P. Goetz, MD
Breast Cancer
,
Video
,
SABCS
Conference Correspondent
Dr Matthew Goetz explains the rationale for using CDK4/6 inhibitors in patients with HR-positive metastatic breast cancer.
Read More ›
New Oral SERD Elacestrant Shows Efficacy in Breast Cancer Harboring ESR1 Mutations
SABCS
Conference Correspondent
The new oral selective estrogen receptor degrader (SERD) elacestrant demonstrates potent antitumor activity in in vitro models, with additive effects to CDK4/6 inhibitors.
Read More ›
CDK6 Could Be a Key Factor for Efficacy of CDK4/6 Inhibitors and the Hormone Sensitivity Following Acquired Resistance
SABCS
Conference Correspondent
CDK6 may be a useful biomarker in patients with estrogen receptor–positive breast cancer who develop acquired resistance to CDK4/6 inhibitors, and inhibition of the PI3K/Akt/mTOR pathway may be a reasonable therapeutic approach for these patients.
Read More ›
Therapeutic Targeting of CDK4/6 Inhibitor–Resistant Breast Cancer
SABCS
Conference Correspondent
An underlying mechanism of combined endocrine therapy and CDK4/6 inhibitor resistance in hormone receptor–positive breast cancer is senescent escape, and 2 novel therapeutic strategies have been identified for this disease, including MDM2 inhibition and CDK2 activation.
Read More ›
Loss of Mismatch Repair Predicts Resistance to Endocrine Therapy and Sensitivity to CDK4/6 Inhibitors in ER-Positive Breast Cancer
SABCS
Conference Correspondent
Although there are currently no biomarkers to guide the use of CDK4/6 inhibitors for estrogen receptor (ER)-positive breast cancer, markers of mismatch repair dysregulation could identify patients in whom CDK4/6 inhibition may prevent disease recurrence most effectively.
Read More ›
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Home
Issues
2024
February 2024 - Vol 17 No 1
2023
December 2023 - Vol 16 No 6
October 2023 - Vol 16 No 5
August 2023 - Vol 16 No 4
June 2023 - Vol 16 No 3
April 2023 - Vol 16 No 2
February 2023 - Vol 16 No 1
Issue Archive
Special Issues
Supplements
Guide to New FDA Approvals
Categories
Conference Correspondent
ESMO 2023 - Small Cell Lung Cancer
ONS 2023 - Multiple Myeloma: Wrap-Up
Web Exclusives
OFS Summit
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Media Library
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Rapid Reactions
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CE
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