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SABCS
A Phase 1b Study of Abemaciclib plus Pembrolizumab for Patients with HR-Positive, HER2-Negative Metastatic Breast Cancer
SABCS
Conference Correspondent
The combination of abemaciclib plus pembrolizumab is safe and effective in women with hormone receptor (HR)-positive/HER2-negative metastatic breast cancer.
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Phase 1-2 Trial of Pembrolizumab and Either Doxorubicin or an Aromatase Inhibitor for Triple-Negative or HR-Positive Metastatic Breast Cancer
SABCS
Conference Correspondent
The combination of the PD-1 inhibitor pembrolizumab plus either doxorubicin or an aromatase inhibitor may be a feasible approach to treating triple-negative or hormone receptor (HR)-positive metastatic breast cancer.
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Abemaciclib for the Treatment of Brain Metastases Secondary to HR-Positive Breast Cancer
SABCS
Conference Correspondent
Abemaciclib demonstrated efficacy and an acceptable safety profile in treating brain metastases in hormone receptor (HR)-positive/HER2-negative breast cancer, but was not effective for brain metastases in HR-positive/HER2-positive breast cancer.
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Phase 2 Study of the Feasibility and Safety of Radium-223 Dichloride plus Hormonal Therapy and Denosumab for the Treatment of HR-Positive Breast Cancer with Bone-Dominant Metastasis
SABCS
Conference Correspondent
The addition of Ra-223 to hormonal therapy and denosumab is a feasible and safe combination therapy in patients with hormone receptor (HR)-positive breast cancer with bone-dominant metastasis.
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Efficacy and Safety of Abemaciclib in Patients with Liver Metastases in the MONARCH 1, 2, and 3 Studies
SABCS
Conference Correspondent
The combination of abemaciclib plus endocrine therapy is an effective treatment option in patients with hormone receptor–positive, HER2-negative advanced breast cancer with liver metastases, with significantly higher clinical benefits than those derived from single-agent endocrine therapy.
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The Benefit of Abemaciclib in Prognostic Subgroups: An Exploratory Analysis of Combined Data from MONARCH 2 and 3
SABCS
Conference Correspondent
In a subanalysis of the MONARCH 2 and 3 studies, patients with hormone receptor–positive, HER2-negative breast cancer with poor prognostic factors received greater benefit from the addition of abemaciclib to endocrine therapy than those without a poor prognosis.
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The Synergistic Antitumor Activity of Entinostat (MS-275) in Combination with Palbociclib (PD 0332991) in ER-Positive and TN Breast Cancer
SABCS
Conference Correspondent
The combination of the selective histone deacetylase inhibitor entinostat plus a CDK4/6 inhibitor demonstrates greater synergistic antitumor activity against estrogen receptor (ER)-positive breast cancer and triple-negative (TN) breast cancer than either agent alone.
Read More ›
Abemaciclib plus Standard Adjuvant ET versus Standard Adjuvant ET Alone in High-Risk Breast Cancer
SABCS
Conference Correspondent
MonarchE is an ongoing, open-label phase 3 study designed to evaluate invasive disease-free survival in patients with hormone receptor‒positive, HER2-negative advanced breast cancer receiving abemaciclib plus standard-of-care adjuvant endocrine therapy (ET).
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US Treatment Patterns for Young Women with HR-Positive, HER2-Negative Metastatic Breast Cancer in the Era of CDK4/6 Inhibitors
SABCS
Conference Correspondent
In a retrospective cohort study of more than 17,000 patients with hormone receptor (HR)-positive, HER2-negative breast cancer, changes in the treatment paradigm have more young patients receiving ovarian suppression as part of initial therapy, and patients regardless of age receiving treatment with the CDK4/6 inhibitor palbociclib, whereas a decrease has been seen in use of tamoxifen for younger patients and overall.
Read More ›
Quality of Life and Patient-Reported Outcomes in US Patients Enrolled in the MONALEESA-2 Study
SABCS
Conference Correspondent
In the MONALEESA-2 study, the CDK4/6 inhibitor ribociclib, in combination with letrozole, led to significant prolongation of progression-free survival while maintaining quality of life in postmenopausal women with advanced breast cancer.
Read More ›
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Issues
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2024
February 2024 - Vol 17 No 1
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Issue Archive
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Guide to New FDA Approvals
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ESMO 2023 - Small Cell Lung Cancer
ONS 2023 - Multiple Myeloma: Wrap-Up
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