Special Issues

At 5 years of follow-up of the VISTA trial, the combination of bortezomib plus melphalan and prednisone (VMP) demonstrated a survival advantage over MP alone as up-front treatment of patients with multiple myeloma who were not transplant candidates. At a median followup of 60.1 months, the absolute difference in overall survival (OS) between the treatment arms was 13 months, according to final results presented at the 53rd Annual Meeting of the American Society of Hematology. Read More ›

The best strategy for management of low-tumor-burden follicular lymphoma (FL) following response to induction therapy is controversial. The phase 3 RESORT study compared maintenance rituximab therapy versus rituximab retreatment at disease progression, and results suggest that retreatment is the preferred approach. The study was presented at the 53rd Annual Meeting of the American Society of Hematology.

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The need to optimize the treatment of patients with cancer while using healthcare resources wisely—in other words, providing “value-based cancer care”—is not a topic of debate, but how to achieve this pressing goal is far from clear. In a panel discussion during the Association for Value-Based Cancer Care’s Second Annual Conference, held in Houston, Texas, strategists from the payer side of the issue discussed the current trends and the challenges they are facing.

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At the Association for Value-Based Cancer Care (AVBCC) second annual meeting, Winston Wong, PharmD, expressed concerns that the site of delivery of cancer care affects efforts to rein in costs and provide value in cancer care. Wong expanded on this issue in the following interview.

Why do you believe that the site of delivery of cancer care can impact the attempt to rein in costs of cancer care and provide value?

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The inaugural annual conference of the Global Biomarkers Consortium brought together an international panel of oncology experts to explore the rapidly evolving field of biomarker research. Cochairs of the event were Hope S. Rugo, MD, director of Breast Oncology and Clinical Trials Education at the University of California San Francisco, and Rüdiger Hehlmann, MD, PhD, professor of medicine at the University of Heidelberg. Michael Kattan, PhD, Vincent Miller, MD, Edith Perez, MD, and Charles Bennett, MD, PhD, served as session chairs.

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Pazopanib, an angiogenesis inhibitor, achieved meaningful responses in about three-quarters of patients with refractory urothelial cancer in preliminary clinical trial results presented at a press briefing during the 2012 Annual Meeting of the American Association for Cancer Research (AACR) in Chicago, Illinois.

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Aspecific subgroup of women with early-stage breast cancer may be able to avoid adjuvant radiation, according to a presentation at the 2012 Annual Meeting of the American Association for Cancer Research (AACR) held in Chicago, Illinois. Women with the luminal A subtype of breast cancer, particularly those older than age 60, had fewer local recurrences at 10 years when treated with tamoxifen alone versus tamoxifen plus radiation therapy in a post hoc analysis of a randomized trial that compared these 2 forms of treatment.

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Contemporary treatment options have improved survival in cancer patients, making it more important than ever to focus on quality-of-life issues such as fertility in survivors of childbearing age. The majority of radiologists and medical oncologists appear to appreciate the need for attention to fertility in age-appropriate patients, according to a study published online ahead of print in Practical Radiation Oncology (Gwede C, et al. 2012). Read More ›

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