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February 2024 - Vol 17 No 1
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2020 Year in Review - Acute Myeloid Leukemia
2020 Year in Review - AML
Escalated Dosing Schedules of CC-486 Effective for Patients Experiencing First AML Low Blast Count Relapse
Leukemia
2020 Year in Review - AML
For patients with AML in the QUAZAR AML-001 trial who relapsed with 5% to 15% blasts on-study, an escalated 21-day CC-486 (oral azacitidine) dosing regimen was well-tolerated and restored remission in approximately 25% of patients.
Read More ›
Gilteritinib + Azacitidine or Azacitidine Alone in Patients with Newly Diagnosed, FLT3-Mutated Acute Myeloid Leukemia
Leukemia
2020 Year in Review - AML
A study comparing gilteritinib + azacitidine with azacitidine alone in patients with newly diagnosed,
FLT3
-mutated AML showed no new safety signals associated with gilteritinib. The safety cohort showed a composite response rate of 67% for gilteritinib + azacitidine.
Read More ›
Comparative Effectiveness of Glasdegib or Venetoclax in Combination with Low-Dose Cytarabine Using Simulated Treatment Comparisons
Leukemia
2020 Year in Review - AML
Adjusted simulated treatment comparisons showed that the overall survival hazard ratios favored glasdegib plus low-dose cytarabine (LDAC) over venetoclax plus LDAC numerically, but not statistically.
Read More ›
Phase 1b/2 Study of Ivosidenib with Venetoclax ± Azacitidine in IDH1-Mutated Hematologic Malignancies
Leukemia
2020 Year in Review - AML
This study of 19 patients with
IDH2-
mutated acute myeloid leukemia indicates that a combination of the
IDH2
inhibitor ivosidenib combined with venetoclax with or without azacitidine is effective and well-tolerated, warranting further study.
Read More ›
Safety and Efficacy of Decitabine + Ipilimumab in Relapsed/Refractory MDS/AML in Posttransplant or Transplant-Naïve Settings
Leukemia
2020 Year in Review - AML
In this study, in patients with relapsed/refractory or secondary myelodysplastic syndromes (MDS)/acute myeloid leukemia (AML), decitabine + ipilimumab exhibited encouraging clinical activity, with an anticipated adverse event profile.
Read More ›
The First-in-Class Anti-CD47 Antibody Magrolimab + Azacitidine Is Well-Tolerated and Effective in Patients with AML
Leukemia
2020 Year in Review - AML
This phase 1b study demonstrated that adding the novel macrophage-targeting immunotherapy magrolimab to azacitidine is well-tolerated and effective for treating patients with AML who are unfit for chemotherapy.
Read More ›
Venetoclax Added to Cladribine plus Low-Dose Ara-C Alternating with 5-Azacitidine in Older Patients with Newly Diagnosed Acute Myeloid Leukemia
Leukemia
2020 Year in Review - AML
Venetoclax added to the low-intensity backbone of cladribine plus low-dose cytarabine (Ara-C) alternating with 5-azacitidine was an effective regimen that was well-tolerated among patients with acute myeloid leukemia.
Read More ›
MBG453 in Combination with Hypomethylating Agents in Patients with High-Risk Myelodysplastic Syndrome or Acute Myeloid Leukemia
Leukemia
2020 Year in Review - AML
MBG453 combined with decitabine or azacitidine was safe and well-tolerated by patients with myelodysplastic syndrome or acute myeloid leukemia. Both combinations showed encouraging antileukemic activity and response rates.
Read More ›
Phase 2 Study of CPX-351 plus Venetoclax in Patients with Acute Myeloid Leukemia
Leukemia
2020 Year in Review - AML
Among patients with relapsed/refractory acute myeloid leukemia, CPX-351 plus 7 days of venetoclax was tolerable and demonstrated encouraging activity.
Read More ›
Decitabine + Venetoclax Compared with Intensive Chemotherapy in AML: A Propensity Score–Matched Analysis
Leukemia
2020 Year in Review - AML
Superior outcomes were observed for older patients with AML receiving decitabine + venetoclax for 10 days versus intensive chemotherapy in a propensity score–matched analysis, particularly for those at high risk for treatment-related mortality.
Read More ›
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Home
Issues
2024
February 2024 - Vol 17 No 1
2023
December 2023 - Vol 16 No 6
October 2023 - Vol 16 No 5
August 2023 - Vol 16 No 4
June 2023 - Vol 16 No 3
April 2023 - Vol 16 No 2
February 2023 - Vol 16 No 1
Issue Archive
Special Issues
Supplements
Guide to New FDA Approvals
Categories
Conference Correspondent
ESMO 2023 - Small Cell Lung Cancer
ONS 2023 - Multiple Myeloma: Wrap-Up
Web Exclusives
OFS Summit
Interview with the Innovators
Drug Updates
Media Library
Videos
Rapid Reactions
Audiocasts
Ask the Experts
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Quick Quiz
CE
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