Objective response rates, median progression-free survival, and overall survival increased in patients with metastatic renal cell carcinoma (RCC) and sunitinib-induced hypertension, according to results of a retrospective analysis of more than 500 RCC patients treated with sunitinib. The rate of adverse events did not increase in hypertensive patients, except for renal adverse events (5% vs 3%). Because of the ease of clinical monitoring, the researchers concluded that, if prospectively validated, sunitinib-induced hypertension will make a desirable biomarker in these patients.
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Pancreatic neuroendocrine tumor (PNET) refers to several tumor types located in the pancreas. These tumors are classified as functional or nonfunctional depending on production and secretion of bioactive hormones. Functional PNETs cause clinical symptoms associated with their tumor classification. Read More ›
Clear cell (CC)-renal cell carcinoma (RCC), the predominant histologic type of RCC, is highly dependent on angiogenesis, via the vascular endothelial growth factor (VEGF) pathway.1 The mammalian target of rapamycin (mTOR) pathway also appears to play a role in VEGF production, as well as directly promote tumor cell growth.
Over the past year, data regarding 2 specific ovarian cancer management strategies have generated considerable interest within the clinical gynecologic cancer community among patients, clinicians, and researchers. One strategy involves the use of bevacizumab (Avastin), and the other approach centers on poly(ADPribose) polymerase (PARP) inhibitors.
When initial androgen-deprivation therapy (ADT) fails to control progression of metastatic prostate cancer, the disease is redefined as castration-resistant prostate cancer (CRPC). Studies have shown that using docetaxel and prednisone to treat men with CRPC only modestly extends median overall survival (OS) to ~19 months. Read More ›
Even though palliative care has been an important aspect of medical care in the United States for more than 25 years, it has yet to gain full public acceptance. Attempts to offer advanced care planning that allows patients to focus on care consistent with their values and preferences have been met with resistance. On January 1, 2011, Medicare proposed clinician reimbursement for advanced care planning. Within several weeks, however, this recommendation was reversed because some politicians worried the public would equate advanced care planning with healthcare rationing. Read More ›
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