Articles

Despite their frailty and comorbidities in the elderly patient population, palbociclib was proven to be a well-tolerated treatment in elderly patients with advanced, ER-positive, HER2-negative breast cancer. Read More ›

Dalpiciclib plus fulvestrant has been clinically demonstrated to significantly improve progression-free survival and reduce the risk for disease progression or death. Read More ›

Abemaciclib plus nonsteroidal aromatase inhibitors were shown to be a successful initial treatment in a Japanese subpopulation, with a tolerable safety profile, consistent with findings in the whole population in treating patients with HR-positive, HER2-negative advanced breast cancer. Read More ›

Olaparib monotherapy has shown promising clinical results in treatment-naïve TNBC with germline or somatic homologous repair deficiency, with fewer adverse events compared with traditional chemotherapy. Read More ›

CDK4/6 inhibitors in combination with antiestrogen therapy are the standard of care for HR-positive, HER2-negative advanced breast cancer. However, a diverse landscape of resistance to these therapies exists, which has resulted in precision-guided therapeutic strategies that are under active clinical development. Read More ›

Improved knowledge of the biologic pathways, along with a number of new targeted therapies, has resulted in better outcomes for patients with HR-positive, HER2-negative breast cancer. These new therapies have been used in combination with older treatments to optimize patient outcomes. Read More ›

PARP inhibitors and immune checkpoint inhibitors have changed the breast cancer landscape, with trials that show improved progression-free survival and overall survival. Read More ›

Two new antibody–drug conjugates with a topoisomerase I inhibitor payload have recently been added to the therapy options for patients with metastatic TNBC and HER2-positive breast cancer. Read More ›

In October 2021, trastuzumab deruxtecan was granted Breakthrough Therapy Designation by the FDA in the United States for the treatment of adult patients with unresectable or metastatic HER2-positive breast cancer who have received ≥1 previous anti-HER2–based regimens. Read More ›

SASCIA was a phase 3 trial evaluating sacituzumab govitecan, an antibody–drug conjugate that received accelerated approval from the FDA in 2020 for the treatment of patients with metastatic TNBC who have received ≥2 previous therapies for metastatic disease. Read More ›