TON - February 2020, Vol 13, No 1

TON February 2020, Vol 13, No 1 Cover

Practice-Changing Results: Ivosidenib First Targeted Therapy to Show Benefits in Patients with Cholangiocarcinoma and IDH1 Mutation

Barcelona, Spain—Ivosidenib (Tibsovo), an oral therapy that targets isocitrate dehydrogenase-1 (IDH1) mutation, significantly improved progression-free survival (PFS) in patients with advanced cholangiocarcinoma (CCA) and an IDH1 mutation, in a phase 3 clinical trial reported lead investigator Ghassan K. Abou-Alfa, MD, Medical Oncologist, Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York City, at the ESMO Congress 2019.

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Palliative Care Improves Pain Control with Less Opioids in Advanced Cancer

San Francisco, CA—Reducing pain without increasing opioids is feasible in patients with advanced cancer, according to results presented at the 2019 ASCO Supportive Care in Oncology Symposium. In a retrospective analysis of 300 patients with advanced cancer receiving inpatient palliative care services, researchers found that nearly half of patients who achieved clinically improved pain did so without an increase in oral morphine equivalent daily dose.

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Greater Social Support May Help Alleviate Pain in Patients with Cancer

San Francisco, CA—According to results from a retrospective analysis of nearly 12,000 patients with cancer, increased social support may function as an analgesic and help to mitigate pain.

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Real-World Healthcare Utilization and Costs Support Broader Use of CAR T-Cell Therapy

Orlando, FL—Chimeric antigen receptor (CAR) T-cell therapy is now approved as third-line treatment for patients with B-cell lymphomas and leukemias. For some patients, CAR T-cell therapy is a miracle therapy, extending survival and, in some cases, as a bridge to a potentially curative transplant. But at an estimated cost of $375,000 to $475,000 per person, many people have questioned the value of this treatment, and whether it can be delivered effectively to patients not enrolled in clinical trials.

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