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Web Exclusives
Thyroid Cancer Overview
Thyroid Cancer
Web Exclusives
Thyroid cancer is the most common form of endocrine malignancy and its incidence is increasing. Thyroid cancers usually present as painless nodules found upon palpation, and nodules >1 cm should be evaluated as they have a higher potential for being clinically significant cancers.
Read More ›
Rearrangement During Transfection (RET) Fusions in Thyroid Cancers
Thyroid Cancer
Web Exclusives
RET
is a tyrosine kinase receptor that, when fused with a partner molecule, activates oncogenic activity.
RET
abnormalities are found in both papillary and medullary thyroid cancers and are promising targets for treatment.
Read More ›
Medullary Thyroid Cancer Overview
Thyroid Cancer
Web Exclusives
Medullary thyroid cancer (MTC) accounts for 5% of all thyroid cancers. The only curative treatment option for MTC is surgery, but understanding of the
RET
pathway and the development of therapies targeting this pathway may improve outcomes for these patients.
Read More ›
Papillary Thyroid Cancer Overview
Thyroid Cancer
Web Exclusives
Papillary thyroid cancer is the most prevalent thyroid cancer, accounting for 80% of thyroid cancer diagnoses. Prognosis is good for patients with early and aggressive treatment, and the new and emerging therapies targeting the
RET
pathway may improve outcomes for patients with advanced disease.
Read More ›
Treatment for Advanced Thyroid Cancer
Thyroid Cancer
Web Exclusives
Among patients with radioiodine-refractory advanced or metastatic thyroid cancer, tyrosine kinase inhibitors are guideline recommended. New
RET
-specific kinase inhibitors have recently demonstrated positive outcomes for these patients.
Read More ›
Telehealth Coverage Expanded During the COVID-19 Pandemic
Ovarian Cancer
Web Exclusives
In response to the COVID-19 pandemic, CMS has added coverage of telehealth services as part of a push by the agency to accelerate the use of telehealth by removing reimbursement barriers.
Read More ›
Trabectedin Added to Pegylated Doxorubicin May Be Viable Treatment for Recurrent Ovarian Cancer But Platinum Remains Standard of Care
Ovarian Cancer
Web Exclusives
The international phase 3 INOVATYON clinical trial did not meet its primary end point of an improvement in overall survival with trabectedin added to pegylated liposomal doxorubicin (PLD) followed by platinum at progression compared with carboplatin plus PLD in patients with recurrent ovarian cancer. Trabectedin plus PLD may still have a role in patients with multiple previous lines of platinum.
Read More ›
NORA Clinical Trial Confirms Efficacy of Individualized Niraparib Starting Dose to Treat Platinum-Sensitive Ovarian Cancer
Ovarian Cancer
Web Exclusives
In the treatment of patients with platinum-sensitive, recurrent ovarian cancer, a lower starting dose of niraparib in patients with a low body weight (77 kg) or low platelet count (150,000/μL) had similar efficacy as the fixed 300-mg starting dose versus placebo on the end point of progression-free survival, confirming a previous observation.
Read More ›
Increased Uptake of Neoadjuvant Chemotherapy Does Not Explain Trend Toward Improved Survival in Advanced Ovarian Cancer
Ovarian Cancer
Web Exclusives
A review of the National Cancer Database reveals that use of neoadjuvant chemotherapy for advanced epithelial ovarian cancer increased markedly between 2004 and 2016. At the same time, median survival improved by more than 6 months. Study authors found no association between the 2 trends.
Read More ›
Platinum-Based Chemotherapy Following Progression on PARP Inhibitor Maintenance Yields Greatest Benefit in Advanced Ovarian Cancer with Platinum-Free Interval >12 Months
Ovarian Cancer
Web Exclusives
Data from a real-world setting show that a platinum-free interval >12 months was associated with the best outcomes after progression on PARP inhibitor maintenance in patients with high-grade serous ovarian cancer.
Read More ›
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Best Practices in Breast Cancer Therapy | OFS
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CE
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