Articles

Women with Small Breast Tumors Could Benefit from Trastuzumab Treatment

Adjuvant trastuzumab treatment may be beneficial for women with small human epidermal growth factor receptor 2 (HER2)-positive breast tumors, according to a review by British researchers.

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Approximately half of colorectal and cervical cancer cases and one third of breast cancer cases are still diagnosed at a late stage of disease, according to a Surveillance Summary released by the US Centers for Disease Control and Prevention (CDC) in the November 26 issue of Morbidity and Mortality Weekly Report.

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Endosonography combined with surgical staging has greater sensitivity for detecting mediastinal nodal metastases, according to results of a randomized, controlled trial published in the November 24 issue of JAMA.

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Errors in clinical staging of localized prostate cancer occur frequently, particularly when transrectal ultrasound (TRUS) is used to detect abnormalities, a new study suggests.

The study showed that in more than a third of cases, the cancer staging assignment was incorrect, casting doubt on the utility of a staging system for localized prostate cancer based on digital rectal examination (DRE) and TRUS.

Supportive Care

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Guidelines specific to cancer patients needed
More education about assessment and management of cardiotoxicity would strengthen the quality of nursing care of cancer patients, according to a study presented at the Oncology Nursing Society’s 2010 Advanced Practice Nursing /Institutes of Learning (APN/IOL)Conference in Orlando, Florida.

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ORLANDO—Minocycline, given before the start of treatment with cetuximab and chemoradiotherapy, plus topical pimecrolimus as needed, can reduce the severity of cetuximab-induced skin toxicity in patients with non–small-cell lung cancer (NSCLC), according to researchers from The Netherlands.

Supportive Care

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ORLANDO—Women who are on intravenous (IV) chemotherapy regimens for recurrent ovarian carcinoma are at risk for nonadherence or nonpersistence with their treatment. But telephone support by an advance practice nurse (APN) can lower this risk and even boost compliance, a new, nonrandomized study suggests.

TON - Daily

Using a cough suppressant syrup as a probe could help physicians determine how well an individual breast cancer patient metabolizes tamoxifen, according to a study presented at the 22nd EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics in Berlin. This would enable physicians to identify patients with altered metabolism and use this information to personalize treatment, making it more effective and reducing the risk of side effects, the researchers say.

Two Cancer Drugs Receive FDA Approval

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The US Food and Drug Administration this week approved denosumab (XGEVA, Amgen) for prevention of skeletal-related events (SREs) in patients with bone metastases from solid tumors. Also this week, approval was granted for eribulin mesylate injection (Halaven, Eisai) for treatment of metastatic breast cancer.

Denosumab

TON - Daily

Treating patients with advanced hepatocellular carcinoma (HCC) with a combination of doxorubicin and sorafenib may increase median time to progression, overall survival, and progression-free survival compared with doxorubicin alone, a new study suggests.

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