Articles

The US Food and Drug Administration (FDA) has issued a warning against using the injectable form of dolasetron mesylate to prevent nausea and vomiting associated with cancer chemotherapy. New data shows that dolasetron can increase the risk for developing abnormal heart rhythms. The oral tablets of dolasetron may be still be used for this indication; however, a strong warning is being added to the drug’s label.
 
Patients with congenital QT syndrome or other underlying heart rate or rhythm problems should not receive either form of the drug.
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The US Food and Drug Administration’s decision to revoke the breast cancer indication for bevacizumab (Avastin) announced last week (http://www.theoncologynurse.com/article/fda-starts-withdrawal-process-avastins-breast-cancer-indication) has drawn mixed response from healthcare professionals and organizations involved in the care of women with breast cancer.
 
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The US Food and Drug Administration (FDA) has begun its process to remove the breast cancer indication from bevacizumab’s (Avastin, Genentech) label. Its decision to move forward is based on a recommendation by it advisory committee composed mainly of oncology.
 
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Patients with cancer have a fivefold increased risk of developing listerosis compared with patients with other predisposing conditions and should be advised to take precautions to avoid food-borne infections, British researchers report.
 
Listerosis, caused by the bacterium Listeria monocytogenes is rare, but can be serious in patients with cancer or others with suppressed T-cell–mediated immunity due to the disease or its treatment. 
 
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Regular use of SPF 15+ sunscreen may prevent the development of melanoma in adults, results of a community-based study indicate. The study is the first prospective, randomized study of the relationship between sunscreen use and melanoma.
 
Adèle Green and her colleagues of the Queensland Institute of Medical Research, Australia, randomized 1621 white adults (25 to 75 years of age) living in a township in Queensland to daily or discretionary sunscreen application to head and arms; the broad-spectrum sunscreen used had a SPF of 16.
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Patient-specific treatment plans devised using images from a combination of single photon emission computed tomography (SPECT) and computed tomography (CT) may reduce radiation-induced lymph node damage without sacrificing treatment outcomes, according to a small study released at the San Antonio Breast Cancer Symposium this past weekend.
 
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Transvaginal ultrasound has high sensitivity and specificity for detecting endometrial cancer in asymptomatic postmenopausal women, according to a study published online at The Lancet Oncology. Although the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) has yet to determine the role of population screening for endometrial cancer, these findings can be applied currently in women with increased endometrial thickness who undergo a pelvic scan for reasons other than vaginal bleeding.
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ORLANDO—Breakthrough pain in cancer patients can be managed easily and effectively with fentanyl pectin nasal spray, according to new data.

Minocycline, given before the start of treatment with cetuximab and chemoradiotherapy, plus topical pimecrolimus as needed, can reduce the severity of cetuximab-induced skin toxicity in patients with non–small-cell lung cancer (NSCLC), according to researchers from The Netherlands.

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ORLANDO—Women who are on intravenous (IV) chemotherapy regimens for recurrent ovarian carcinoma are at risk for nonadherence or nonpersistence with their treatment. But telephone support by an advanced practice nurse (APN) can lower this risk and even boost compliance, a new, nonrandomized study suggests.

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Patients with stage III colorectal cancer who experience surgical complications are at increased risk for omission of chemotherapy and for delay in adjuvant chemotherapy, according to a new study in the December issue of Diseases of the Colon & Rectum.
 
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