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New Studies Provide Insights into Cognitive Impairments in Cancer Patients

Although commonly referred to as “chemobrain” and described most often in women with breast cancer, cognitive impairments may occur in patients with other types of cancer and after hormonal and radiation therapies as well, a new study suggests. Another recent study was the first to use imaging to show changes in brain tissue in women undergoing chemotherapy.

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Preliminary results of an ongoing trial suggest that a combination of trastuzumab, bevacizumab, and docetaxel is safe and effective as first-line therapy in women with metastatic breast cancer (MBC).

Fourteen of the 18 patients treated to date had a partial response or stable disease, a clinical benefit rate of 77.7, the investigators report.

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Adding the monoclonal antibody rituximab to chemotherapy signicantly increases both progression-free and overall survival in previously untreated patients with chronic lymphocytic leukemia (CLL), the German Lymphocytic Leukemia Study Group reports.

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The recently approved taxane cabazitaxel significantly improved overall survival in men with castration-resistant prostate cancer in a multinational phase 3 study.

The TROPIC investigators found that men treated with cabazitaxel plus prednisone had 30% lower risk of death compared with patients treated with mitoxantrone plus prednisone.

TON - Daily

Results of a trial by the Children's Oncology Group indicate that children with intermediate-risk neuroblastoma can be successfully treated with a shorter duration and lower doses of chemotherapy than are currently used.

Findings from the phase 3 trial reported in the September 30, 2010, issue of the New England Journal of Medicine may change the approach to treating the disease, which affects 650 children in the United States each year.

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Surgery provides excellent long-term cancer control and high survival rates for men with aggressive prostate cancer, a new study suggests.

In the study by researchers from the Mayo Clinic, Rochester, Minnesota, and Fox Chase Cancer Center, Philadelphia, men with high-risk prostate cancer who underwent radical prostatectomy had a 10-year cancer-specific survival rate of 92% and an overall survival rate of 77%.

TON - Daily

Findings of a new study demonstrate the benefit of early referral of young women with breast cancer to reproductive specialists for fertility preservation.

The study, reported online September 27 in the Journal of Clinical Oncology, showed that referral to reproductive specialists before breast surgery increases the likelihood of obtaining a sufficient number of oocytes for fertility preservation without delaying breast cancer treatment.

TON - Daily

Findings of a large new study point to the potentially devastating impact of a cancer diagnosis on the mental health of a patient’s partner and the importance of involving family members in treatment.

The study of Danish men showed that men whose partners were diagnosed with breast cancer were significantly more likely to be hospitalized with an affective disorder than men whose partners did not have breast cancer. The results are reported in the September 27 online edition of Cancer.

Hematologic Cancers

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Women who have difficulty performing normal activities of daily living after an initial treatment for breast cancer have reduced overall survival compared with survivors without functional limitations, results of a long-term study indicate.

“Our study provides evidence of why it is important to develop interventions that improve physical function, to mitigate the adverse effects of physical limitations,” said lead author Dejana Braithwaite, PhD, of the University of California San Francisco.

TON - Daily

Dexrazoxane provides long-term protection against against doxorubicin-induced heart damage in survivors of childhood high-risk acute lymphoblastic leukemia (ALL) and does not compromise oncologic efficacy, a new multicenter study indicates.

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