Articles

Discontinuation of imatinib therapy puts patients with advanced gastrointestinal stromal tumors (GIST) at high risk for rapid disease progression and is not recommended unless substantial toxicity develops, according to French researchers.
 
After nearly 3 years of follow up, 2-year progression-free survival was 80% in patients who remained on imatinib but only 16% in those whose treatment was stopped.
 
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Regular consumption of three to four alcoholic drinks per week increases the risk of breast cancer recurrence and death from breast cancer, a study of breast cancer survivors suggests. Postmenopausal and overweight or obese women are at greatest risk.
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A man’s level of prostate specific antigen (PSA) at age 60 predicts his lifetime risk of metastasis and death from prostate cancer, a study of Swedish men indicates.
 
The findings, published online September 14 in BMJ, could be useful in determining which men should be screened for prostate cancer after the age of 60 and which may not benefit substantially from continued screening.
 
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In a case-control study, regular use of 75 mg/day of aspirin— lower than the standard 81-mg dose of baby aspirin—significantly reduced the risk of developing colorectal cancer (CRC). The effect was evident after 1 year and increased with longer use.
 
The findings of this large population-based study are applicable to the general population, not just high-risk patients, according to the authors.
 
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Patients with advanced cancer who die at home have greater quality of life (QOL) than patients who die in a hospital or intensive care unit. In addition, their caregivers experience less bereavement-related psychiatric illnesses, according to a study published online at the Journal of Clinical Oncology.
 
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Methylphenidate (MPH), a drug used to treat attention deficit hyperactivity disorder in healthy children also has long-term benefits for childhood cancer survivors, a new study indicates.
 
After 12 months of treatment with MPH, children showed significant improvements on measures of attention, social skills, and behavior compared with a control group of children who did not receive MPH.
 
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CHICAGO—Several new agents elicited excitement for the treatment of women with advanced breast cancer, including a novel cytotoxic agent that is the first to improve survival as mono therapy in this challenging patient population.

In an international study, patients with metastatic breast cancer refractory to numerous treatments lived 2.5 months longer when treated with eribulin mesylate, a synthetic analog of the novel halichondrin B family, versus single agents alone.

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SAN FRANCISCO—Two new studies presented at the 2010 annual meeting of the American Urological Association (AUA) suggest that large-scale prostate cancer screenings can indeed save lives.

Researchers in Innsbruck, Austria, evaluated data from the state of Tyrol within Austria, where an early detection and treatment program has been in place for more than 20 years. They found that these programs have been associated with a reduction in mortality in areas where effective treatment is available to all men.

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SAN FRANCISCO—Prostate cancer patients undergoing three-dimensional external beam radiation therapy (3DEBRT) for prostate cancer may be at an increased risk of hip fracture and could benefit from additional measures to improve bone health following treatment, according to a study by Minneapolis researchers. Read More ›


Once-yearly Histrelin Implant Provides Sustained Improvement in Prostate Cancer Patients

BARCELONA—Investigators have documented the long-term efficacy and tolerability of a once-yearly histrelin subdermal implant in men with advanced prostate cancer.

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